Queen Victoria’s eighth child and fourth son came into the world at Buckingham Palace on April 7, 1853. After seven children, the Queen knew what to expect in childbirth, and she wasn't looking forward to it. So when her personal physician, Sir James Clark, made a radical suggestion, she was all for it—and so the Queen of England became an early adopter of chloroform to help ease the pain of childbirth. She was so delighted with the results that she publicly endorsed the drug’s use, much to the ire of the medical establishment of the time, which felt that pain in childbirth was divinely ordained. Her Majesty thought otherwise.So it was with relative ease that Prince Leopold George Duncan Albert arrived in the royal family…perhaps the last time anything associated with his life would be easy. He was not an attractive child; and coming after handsome and sunny-natured Arthur, the Queen’s favorite, made his unattractiveness seem even worse. Fortunately, the two brothers loved each other dearly, and would be close all their lives.
But how long would that life be, in Leopold’s case? For not long after his second birthday, disturbing hints that his health was not good began to occur. Though it would be a few years before Leopold’s diagnosis would be confirmed, that year marked the appearance of symptoms of his hemophilia. Unfortunately, Leopold did not like to be coddled: despite his fragility he was an active, adventurous boy, which of course led to accidents. Something as small as a bruised knee could lay him up for weeks of agony and bed-rest, which would make anyone fractious and difficult to deal with. Moreover, he was intelligent (probably the cleverest of the royal sons) and liked to argue—which did not endear him to his mother.
In March 1884, Leopold was visiting the south of France as he often did to escape England’s cold, damp winters. A slip on the tiled floor of the villa where he was staying led to a painfully bruised knee and more bed-rest…but this time, Leopold did not recover. He died in the night, whether due to an unknown deep hemorrhage, too much morphine, or an attack of epilepsy. His dear Helen gave birth to their second child, a son, four months later, who inherited his father’s title of Duke of Albany.

But starting in the 1840s, that began to change. Advances in the study of chemistry in the 18th and early 19th centuries led to the study of gases, among them ether and nitrous oxide. American doctors in Boston and in Georgia began experimenting with using ether during surgery, with growing success. Nitrous oxide, after some initial problems (during its first public use in a dental procedure the patient woke up too soon and began to scream) came into wide use. But it was the development and use of chloroform that really opened the field of pain control in surgery. It was developed in 1847 by a Scottish obstetrician named James Young Simpson who wanted to find an anesthetic to give women in labor. Although many doctors fought against its use because of that supposed biblical injunction, its popularity and widespread use were guaranteed after Queen Victoria chose to use it during the births of her son Leopold in 1853 and daughter Beatrice in 1857 and was vocal in its praise, even in the face of censure from Britain's premier medical journal, The Lancet. After having born seven children without the benefit of anesthesia, she knew what she was talking about!